Team news
Manchester United defenders Harry Maguire and Lisandro Martinez have both returned to training this week.
Jonny Evans will be assessed after missing Thursday’s Europa League win.
Everton forwards Armando Broja and Youssef Chermiti will play for the under-23 team on Friday as they continue to build fitness following long-term injuries.
Captain Seamus Coleman is back in training but is unlikely to feature at Old Trafford.
James Garner and Tim Iroegbunam remain out.
Match facts
Head-to-head
Manchester United have won 41 Premier League games against Everton, the highest tally of any side in the competition against one opponent.
Sean Dyche's Everton have lost and failed to score in all three Premier League fixtures versus United, including a 2-0 away defeat in March when Bruno Fernandes and Marcus Rashford scored penalties.
The Toffees have won just two of their 32 Premier League visits to Old Trafford, most recently in 2013.
Manchester United
Manchester United's tally of 16 points equals their lowest total after 12 Premier League games.
There have been 26 goals scored in Premier League matches involving Manchester United this campaign, a joint-league low alongside Newcastle United. Everton's matches have produced only 27 goals.
United have scored 13 goals from an expected goals tally of 18.3 in the Premier League this term, the biggest negative differential of any team.
Ruben Amorim won all 22 of his home league games in charge of Sporting Lisbon from the start of last season, by an aggregate score of 72-13.
In their first two games under Amorim, United opened the scoring after 81 seconds against Ipswich Town and 48 seconds versus Bodø/Glimt.
Marcus Rashford scored in his first Premier League appearance under Louis van Gaal, José Mourinho, Ole Gunnar Solskjær and Amorim. He failed to net in his second league game under those previous three managers.
Rashford has been directly involved in five goals in his past seven Premier League games against Everton, scoring in the last two.
Amorim played in both of Benfica's matches against Everton in the 2009-10 Europa League group stage, winning 5-0 at home and 2-0 away.
Everton
Everton have lost one of their last eight Premier League matches, having started the season with four straight defeats.
However, the Toffees have won only two of their 12 league games so far.
Everton have failed to score in a league-high six fixtures, although only Liverpool and Manchester United have kept more clean sheets than the Toffees' four.
In the last eight matchrounds, Everton have let in a league-low four goals.
They have won only one of their last 17 Premier League away matches, a 2-0 victory at Ipswich Town in October.
Everton can go four successive league fixtures without scoring for the first time since March 2022 under Frank Lampard.
They have played 701 long balls this season, more than any other club.
Dwight McNeil’s 30 chances created this term is almost twice as many as any other Everton player.
Sean Dyche has won only one of his 17 Premier League matches as a manager versus Manchester United, Burnley's 2-0 victory at Old Trafford in January 2020. The Clarets team included James Tarkowski and Dwight McNeil.